Even if everything that has happened so far does not seem to lead to other epilogues other than the definitive cancellation of the series, apparently not all is lost for The Big Bang Theory and for their fans. Kaley Cuoco (actress who plays Penny) has spoken about it during the last Golden Globes, and with her declarations hopes are back. In fact he stated that there are chances that the series will receive something new in the next few years, like some sort of reboot or spin off, most likely dedicated only to a part of the cast.
However, at the moment we have no news on which path he wants to take CBS, especially also to the will of Jim Parsons (Sheldon Cooper in the series) to devote himself to something else.